Automutation Syndrome is a disorder that effects the Neosapien race.

The Genetic Engineering of the Neosapiens was flawed, so all Neosapiens feared developing the Automutation Syndrome. Although the exact nature of this disorder has never been properly studied, it supposedly involves a Neosapien's DNA becoming unstable, turning his or her body into a pile of mush. The causes include but are not limited to spontaneous degeneration, artificial means, or severe physical trauma. Phaeton, the leader of the Neosapien Commonwealth, himself developed this disorder after his fall from Olympus Mons during a fight against J.T. Marsh, confining him completely to a life support suit for the rest of his life.

At the end of the Neosapien War, there was still no known cure to Automutation Syndrome.

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