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Dark Matter Syndrome is a neurological ailment that afflicts those with extended exposure to Dark Matter. As a result most of those affected are members of the Pirate Clans, many of whom lived on the dark matter planet Chaos or worked on spaceships that utilized dark matter in a cloaking device. Dark Matter Syndrome is symptomized by aggressive and violent tendencies. The actual health threat is minimal unless combined with some other injury.

Dark Matter Syndrome was discovered by Algernon, while treating an injured Jonas Simbacca. Algernon delevoped a treatment of Dark Matter Syndrome consists of full-spectrum therapy which allows complete recovery. Simbacca made a full recovery and most of his aggressive tendencies were gone.

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