Commander Medusa was commanding officer of the Amazon for the Neosapien Commonwealth.
Medusa was first seen serving under the Draconis clone. She alerted Livia to Draconis' dissatisfaction, resulting in his death. She later served under Thrax. When Thrax decided to disobey Livia's orders and surrender during the Fourth Battle of Earth, Medusa tried to stop him but was stunned and locked in a room. A Neo Lord freed her and gave her command of the Amazon garrison.
No sooner did Medusa take charge then she was attacked by Albrecht Ketzer. He mutated her into one of his experiments. She gained the ability to project a blinding light from her eyes. After the war, she fought Thrax and Able Squad when Ketzer attacked them in an attempt to recapture Nara Burns.